ZEB1 anticorps (AA 1074-1124)

N° du produit ABIN7454797

L’anticorps Lapin Polyclonal anti-ZEB1 a été validé pour WB, IP et IHC (fp). Il convient pour détecter ZEB1 dans des échantillons de Humain et Souris.

Aperçu rapide pour ZEB1 anticorps (AA 1074-1124) (ABIN7454797)

Antigène: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZEB1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-ZEB1 anticorps

Épitope: AA 1074-1124

Fonction: Rabbit anti-ZEB1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1074 and 1124

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:200 - 1:1000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ZEB1

Antigène: ZEB1 (Zinc Finger E-Box Binding Homeobox 1 (ZEB1))

Autre désignation: ZEB1

Sujet: Background: ZEB1 (zinc-finger E-box-binding homeobox 1), also known as TCF8 (transcription factor 8), is a delta-EF1/ZFH-1 C2H2-type zinc finger that bears seven C2H2-type zinc fingers and one homeobox DNA-binding domain. ZEB1 is a transcriptional repressor of interleukin-2 (IL-2). Mutations in the ZEB1 gene are associated with posterior corneal dystrophy type 3 (PPC3) a rare disorder characterized by metaplasia and overgrowth of corneal endothelial cells. ZEB1 appears to be critical to epithelial to mesenchymal transitions (EMT) during development and cancer metastasis. As a transcription factor involved in EMT, ZEB1 promotes EMT by repressing genes associated with the epithelial phenotype and activates genes associated with the mesenchymal phenotype.

ID gène: 6935

NCBI Accession: NP_110378

UniProt: P37275

Pathways: Regulation of Muscle Cell Differentiation